The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

2013/07/03 by Gijs den Besten, Karen van Eunen, Albert K. Groen +4 · 4,980 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Bacteria #Biochemistry #Biology #Cellular metabolism #Diet and metabolism studies #Dietary Effects on Health #Energy metabolism #Genetics #Gut flora #Gut microbiota and health #Host (biology) #Metabolism #Microbial metabolism

paper · pdf · doi:10.1194/jlr.r036012

published in Journal of Lipid Research 54(9), 2325-2340 (Elsevier BV)

openalex publication_date 2013/07/03 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05

Abstract

Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism. The mechanisms underlying these effects are the subject of intensive research and encompass the complex interplay between diet, gut microbiota, and host energy metabolism. This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism. There are interesting leads on the underlying molecular mechanisms, but there are also many apparently contradictory results. A coherent understanding of the multilevel network in which SCFAs exert their effects is hampered by the lack of quantitative data on actual fluxes of SCFAs and metabolic processes regulated by SCFAs. In this review we address questions that, when answered, will bring us a great step forward in elucidating the role of SCFAs in mammalian energy metabolism.

Citations

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