Clinical Application and Potential of Fecal Microbiota Transplantation

2018/11/07 by Rogier E. Ooijevaar, R.E. Ooijevaar, E.M. Terveer +7 · 343 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotics #Bioinformatics #Biology #Cirrhosis #Clostridioides #Clostridium difficile #Clostridium difficile and Clostridium perfringens research #Colonoscopy #Disease #Dysbiosis #Fecal bacteriotherapy #Feces #Gastroenterology #Gastrointestinal motility and disorders #Gut flora #Gut microbiota and health #Hepatic encephalopathy #Immunology #Internal medicine #Irritable bowel syndrome #Medicine #Microbiology #Microbiome #Rifaximin #Transplantation #Ulcerative colitis

paper · pdf · doi:10.1146/annurev-med-111717-122956

published in Annual Review of Medicine 70(1), 335-351 (Annual Reviews)

openalex publication_date 2018/11/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

Fecal microbiota transplantation (FMT) is a well-established treatment for recurrent Clostridioides difficile infection. FMT has become a more readily available and useful new treatment option as a result of stool banks. The current state of knowledge indicates that dysbiosis of the gut microbiota is implicated in several disorders in addition to C. difficile infection. Randomized controlled studies have shown FMT to be somewhat effective in treating ulcerative colitis, irritable bowel syndrome, and hepatic encephalopathy. In addition, FMT has been beneficial in treating several other conditions, such as the eradication of multidrug-resistant organisms and graft-versus-host disease. We expect that FMT will soon be implemented as a treatment strategy for several new indications, although further studies are needed.

Citations

• The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
• Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
• Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Cited by

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