Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

2017/09/11 by Egle Cekanaviciute, Bryan B. Yoo, Tessel F. Runia +19 · 1,063 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Akkermansia #Akkermansia muciniphila #Autoimmune disease #Bacteria #Biology #Clostridium difficile and Clostridium perfringens research #Dermatology and Skin Diseases #Experimental autoimmune encephalomyelitis #FOXP3 #Gut flora #Gut microbiota and health #Human microbiome #IL-2 receptor #Immune system #Immunology #Lactobacillus #Microbiome #Multiple sclerosis #Pathogenesis #Peripheral blood mononuclear cell #RAR-related orphan receptor gamma #Regulatory T cell #T cell

paper · pdf · doi:10.1073/pnas.1711235114

published in Proceedings of the National Academy of Sciences 114(40), 10713-10718 (National Academy of Sciences)

openalex publication_date 2017/09/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contribute to the proinflammatory environment in vitro and in vivo. Thus, our results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.

Cited by

• The role of the gut microbiota and microbial metabolites in neuroinflammation
• Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity
• The gut microbiome: Relationships with disease and opportunities for therapy
• The Microbiota-Gut-Brain Axis
• Clinical Application and Potential of Fecal Microbiota Transplantation
• Biocontrol effects of three antagonistic bacteria strains against Codonopsis pilosula wilt disease caused by Fusarium oxysporum
• Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease
• The Controversial Role of Human Gut Lachnospiraceae
• The gut microbiota–brain axis in behaviour and brain disorders
• The microbiota-immune axis as a central mediator of gut-brain communication
• Immune mechanisms and shared immune targets in neurodegenerative diseases
• The gut microbiota is an emerging target for improving brain health during ageing
• Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review
• Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli
• Segatella intestinalis sp. nov., and Parabacteroides caeci sp. nov., novel potential probiotics from the human gut microbiome
• Gut-brain communication in demyelinating disorders
• Urban-associated diseases: Candidate diseases, environmental risk factors, and a path forward
• Multiple Sclerosis. [europepmc]
• Neurotransmitter modulation by the gut microbiota. [europepmc]
• Human gut microbiome: hopes, threats and promises. [europepmc]
• Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. [europepmc]
• The gut microbiome: Relationships with disease and opportunities for therapy. [europepmc]
• Microbiome-microglia connections via the gut-brain axis. [europepmc]
• A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist? [europepmc]
• Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. [europepmc]
• Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt + Regulatory T Cells and Exacerbate Colitis in Mice. [europepmc]
• Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. [europepmc]
• Environmental and genetic risk factors for MS: an integrated review. [europepmc]
• Dysbiosis of Gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidney disease. [europepmc]
• Microglia, Lifestyle Stress, and Neurodegeneration. [europepmc]
• Fecal Microbiota Transplantation in Neurological Disorders. [europepmc]
• The Controversial Role of Human Gut Lachnospiraceae. [europepmc]
• HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. [europepmc]
• Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma. [europepmc]
• Gut Microbiome in Progressive Multiple Sclerosis. [europepmc]
• Parabacteroides distasonis : intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health. [europepmc]
• Human gut bacterial metabolism drives Th17 activation and colitis. [europepmc]
• A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders. [europepmc]
• Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease. [europepmc]
• The gut microbiome as a modulator of healthy ageing. [europepmc]
• Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. [europepmc]
• Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity. [europepmc]

Related

• Microbial view of central nervous system autoimmunity
• The role of the gut microbiota and microbial metabolites in neuroinflammation
• Intestinal dysbiosis and probiotic applications in autoimmune diseases
• The Role of Human Microbiota in Autoimmune Diseases: Exploring Dysbiosis and Mechanisms
• The gut microbiome: Relationships with disease and opportunities for therapy