Ageing, immune fitness and cancer

2025/08/14 by Melissa Dolan, Kendra A. Libby, Alison E. Ringel +2 · 1 voice · 30 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Ageing #Biology #Evolutionary biology #Genetics #Gerontology #Immune Cell Function and Interaction #Immune cells in cancer #Immune system #Medicine #Single-cell and spatial transcriptomics

paper · doi:10.1038/s41568-025-00858-z

published in Nature reviews. Cancer 25(11), 848-872 (Nature Portfolio)

openalex publication_date 2025/08/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Citations

• Cellular and molecular biology of aging endothelial cells
• TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells
• Breast cancer‐specific survival by age: Worse outcomes for the oldest patients
• Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
• IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice
• Tumour-infiltrating lymphocytes: from prognosis to treatment selection
• Cancer statistics, 2024
• Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Cited by

• Biological aging and generational shifts in early-onset cancer risk
• Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy
• Hallmarks of cancer—Then and now, and beyond
• Cell populations in human breast cancers are molecularly and biologically distinct with age. [europepmc]
• Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders. [europepmc]
• Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study. [europepmc]
• [Progress in the Immune Mechanism of Microwave Ablation Therapy for Lung Cancer]. [europepmc]
• [Appropriate Duration of First-line Immunotherapy for Advanced NSCLC and Predictive Factors]. [europepmc]
• Real-world pharmacovigilance analysis of pralatrexate using the FDA adverse event reporting system database. [europepmc]
• Organoid: a promising solution to current challenges in cancer immunotherapy. [europepmc]
• The Interplay of Aging and the Immune System. [europepmc]
• From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy. [europepmc]
• Network Rewiring in the Aging Immune System: From Chronic Inflammation to Age-Related Pathologies [europepmc]
• Overcoming resistance to anti-PD-1/PD-L1 therapy in cancer [europepmc]

Discussions

• Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in @natrevcancer.nature.com 🧬 Great to work with @sandramcallister.bsky.social la [bsky, 16 points, 0 comments]