2017/02/20 by Blessing A. Aderibigbe · 67 citations
Medicine · Computer Science · Biochemistry, Genetics and Molecular Biology · Chemistry · #Malaria Research and Control #Computational Drug Discovery Methods #Cancer therapeutics and mechanisms #Artemisinin #Bioavailability #Malaria #Drug #Drug delivery #Pharmacology #In vivo #Drug resistance #Medicine #Chemistry #Plasmodium falciparum #Nanotechnology #Biology #Biotechnology #Materials science #Immunology #Microbiology
paper · pdf · doi:10.3390/molecules22020323
published in Molecules 22(2), 323 (Multidisciplinary Digital Publishing Institute)
openalex publication_date 2017/02/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives.