Pharmacogenomics Knowledge for Personalized Medicine

2012/09/19 by M Whirl-Carrillo, Michelle Whirl‐Carrillo, E M McDonagh +13 · 38 citations
Pharmacology, Toxicology and Pharmaceutics · Computer Science · Biochemistry, Genetics and Molecular Biology · #Pharmacogenetics and Drug Metabolism #Computational Drug Discovery Methods #Nutrition, Genetics, and Disease

paper · doi:10.1038/clpt.2012.96

Abstract

The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. It provides clinically relevant information, including dosing guidelines, annotated drug labels, and potentially actionable gene-drug associations and genotype-phenotype relationships. Curators assign levels of evidence to variant-drug associations using well-defined criteria based on careful literature review. Thus, PharmGKB is a useful source of high-quality information supporting personalized medicine-implementation projects.

Citations

• CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network

Cited by

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• Clinical interpretation and implications of whole-genome sequencing. [europepmc]
• Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing. [europepmc]
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Related

• Pharmacogenomics: Driving Personalized Medicine
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• Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts