Continuous‐Flow Synthesis of the Anti‐Malaria Drug Artemisinin

2012/01/16 by François Lévesque, Peter H. Seeberger · 508 citations
Engineering · Materials Science · Computer Science · Chemistry · #Innovative Microfluidic and Catalytic Techniques Innovation #Gold and Silver Nanoparticles Synthesis and Applications #Computational Drug Discovery Methods #Library science #Chemistry #Nanotechnology #Physics #Computer science #Materials science

paper · doi:10.1002/anie.201107446

published in Angewandte Chemie International Edition 51(7), 1706-1709 (Wiley)

openalex publication_date 2012/01/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.

Citations

• Total synthesis of qinghaosu

Cited by

• A Concise Synthesis of (+)-Artemisinin
• Total Synthesis and Biological Investigation of (−)‐Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific
• Artemisinin [wikipedia]

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