2011/02/16 by Prakash Saha, Julia Humphries, Bijan Modarai +8 · 4 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Venous Thromboembolism Diagnosis and Management #Blood Coagulation and Thrombosis Mechanisms #Inflammasome and immune disorders #Natural history #Thrombosis #Thrombus #Venous thrombosis #Deep vein #Inflammation #Medicine #Vein #Immunology #Pathology #Internal medicine
paper · doi:10.1161/atvbaha.110.213405
openalex publication_date 2011/02/16 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.