2008/08/27 by Bruce Furie, Barbara C. Furie · 5 citations
Medicine · #Blood Coagulation and Thrombosis Mechanisms #Antiplatelet Therapy and Cardiovascular Diseases #Coagulation, Bradykinin, Polyphosphates, and Angioedema #Medicine #Extravasation #Thrombus #Hemostasis #Fibrin #Coagulation #Circulatory system #Thrombin #Tissue factor #Blood vessel #Platelet #Pathology #Cardiology #Surgery #Internal medicine #Immunology
paper · doi:10.1056/nejmra0801082
openalex publication_date 2008/08/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Hemostasis is the process that maintains the integrity of a closed, high-pressure circulatory system after vascular damage. Vessel-wall injury and the extravasation of blood from the circulation rapidly initiate events in the vessel wall and in blood that seal the breach. Circulating platelets are recruited to the site of injury, where they become a major component of the developing thrombus; blood coagulation, initiated by tissue factor, culminates in the generation of thrombin and fibrin. These events occur concomitantly (Figure 1A; also see Video, available with the full text of this article at www.nejm.org), and under normal conditions, regulatory mechanisms contain . . .