2019/01/01 by Delphine Borgel, Elsa P. Bianchini, Dominique Lasne +2 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Venous Thromboembolism Diagnosis and Management #Blood Coagulation and Thrombosis Mechanisms #Inflammasome and immune disorders #Deep vein #Thrombosis #Medicine #Inflammation #Post-thrombotic syndrome #Coagulation #Internal medicine
paper · pdf · doi:10.1080/16078454.2019.1687144
openalex publication_date 2019/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Deep vein thrombosis is a common disease associated with a variety of complications including post-thrombotic syndrome as a late complication. It is now clear that in addition to classical deep vein thrombosis triggers such as blood flow disturbance, hypercoagulability, and vessel wall changes, inflammation has a key role in the pathophysiology of deep vein thrombosis, and there is a close relationship between inflammation and coagulation. As attested by changes in several plasma biomarkers, inflammation may have a significant role in the development of post-thrombotic syndrome. Here, we review the link between inflammation and deep vein thrombosis and thus the potential value of anti-inflammatory and/or anticoagulant drugs in the treatment of deep vein thrombosis and the prevention of post-thrombotic syndrome.