Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus

2020/12/07 by Svenja Ulferts, Bina Prajapati, Robert Grosse +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · #RNA Research and Splicing #Nuclear Structure and Function #Genomics and Chromatin Dynamics #Biology #Actin #Nucleus #Actin remodeling #Cell biology #Cytoskeleton #Chromatin #Formins #Genome #Cell nucleus #Compartment (ship) #Actin cytoskeleton #Cell #Genetics #Gene

paper · pdf · doi:10.1101/cshperspect.a040121

openalex publication_date 2020/12/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Recent years have provided considerable insights into the dynamic nature of the cell nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well as spatiotemporally orchestrating chromatin remodeling and transcription. Remarkably, it has become clear that the ancient and highly conserved cytoskeletal protein actin plays a crucial part in these processes. However, the underlying mechanisms, regulations, and properties of actin functions inside the nucleus are still not well understood. Here we summarize the diverse and distinct roles of monomeric and filamentous actin as well as the emerging roles for actin dynamics inside the nuclear compartment for genome organization and nuclear architecture.

Citations

• Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
• A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes
• Active maintenance of nuclear actin by importin 9 supports transcription
• Long-Range Directional Movement of an Interphase Chromosome Site
• The auxiliary replicons of Butyrivibrio proteoclasticus : a thesis presented in fulfilment of the Doctorate of Philosophy degree at Massey University, Palmerston North, New Zealand
• T cell receptor–triggered nuclear actin network formation drives CD4 + T cell effector functions

Cited by

• Actin [wikipedia]