The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

1999/10/01 by Oleg Shatursky, Oleg Ya. Shatursky, Alejandro P. Heuck +10 · 14 citations
Biochemistry, Genetics and Molecular Biology · Engineering · Environmental Science · #Bacteriophages and microbial interactions #Lipid Membrane Structure and Behavior #Nanopore and Nanochannel Transport Studies

paper · pdf · doi:10.1016/s0092-8674(00)81660-8

crossref issued 1999/10/01 · crossref published 1999/10/01 · crossref published-print 1999/10/01 · openalex publication_date 1999/10/01 · crossref created 2004/05/04 · openalex created_date 2016/06/24 · crossref deposited 2019/02/09 · crossref indexed 2026/05/20 · openalex updated_date 2026/08/01

Citations

• Structure of a Cholesterol-Binding, Thiol-Activated Cytolysin and a Model of Its Membrane Form
• Parallax method for direct measurement of membrane penetration depth utilizing fluorescence quenching by spin-labeled phospholipids

Cited by

• Vertical collapse of a cytolysin prepore moves its transmembrane β‐hairpins to the membrane
• Cholesterol Exposure at the Membrane Surface Is Necessary and Sufficient to Trigger Perfringolysin O Binding
• Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy
• The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly
• Bacterial pore-forming toxins: The (w)hole story?
• Molecular basis of listeriolysin O pH dependence
• Arresting Pore Formation of a Cholesterol-dependent Cytolysin by Disulfide Trapping Synchronizes the Insertion of the Transmembrane β-Sheet from a Prepore Intermediate
• Monomer-Monomer Interactions Drive the Prepore to Pore Conversion of a β-Barrel-forming Cholesterol-dependent Cytolysin
• Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins
• Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins
• Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin
• Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment
• The Cholesterol-Dependent Cytolysin Family of Gram-Positive Bacterial Toxins
• Cholesterol-dependent cytolysin [wikipedia]