Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin

2002/10/07 by Rajesh Ramachandran, Alejandro P. Heuck, Rodney K. Tweten +1 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antimicrobial Resistance in Staphylococcus #Lipid Membrane Structure and Behavior #Streptococcal Infections and Treatments

paper · doi:10.1038/nsb855

crossref issued 2002/10/07 · crossref published 2002/10/07 · crossref published-online 2002/10/07 · openalex publication_date 2002/10/07 · crossref created 2002/10/27 · crossref deposited 2023/05/23 · openalex created_date 2025/10/10 · crossref indexed 2026/03/07 · openalex updated_date 2026/08/01

Citations

• Structure of a Cholesterol-Binding, Thiol-Activated Cytolysin and a Model of Its Membrane Form
• PROCHECK: a program to check the stereochemical quality of protein structures
• Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming Toxin Clostridium perfringens Perfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy
• Monomer-Monomer Interactions Drive the Prepore to Pore Conversion of a β-Barrel-forming Cholesterol-dependent Cytolysin
• The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin
• Arresting Pore Formation of a Cholesterol-dependent Cytolysin by Disulfide Trapping Synchronizes the Insertion of the Transmembrane β-Sheet from a Prepore Intermediate

Cited by

• Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment
• The Cholesterol-Dependent Cytolysin Family of Gram-Positive Bacterial Toxins
• Differential interaction of the two cholesterol‐dependent, membrane‐damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol
• Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins
• Characterization of a Streptococcal Cholesterol-Dependent Cytolysin with a Lewis y and b Specific Lectin Domain
• Cholesterol-dependent cytolysin [wikipedia]