Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

2015/04/07 by John L. Wallace, Rui Wang · 874 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Asthma and respiratory diseases #Bioinformatics #Biology #Cell biology #Chemistry #Computational biology #Hydrogen sulfide #Mast cells and histamine #Mediator #Medicine #Pharmacology #Sulfur Compounds in Biology

paper · doi:10.1038/nrd4433

published in Nature Reviews Drug Discovery 14(5), 329-345 (Nature Portfolio)

crossref issued 2015/04/07 · crossref published 2015/04/07 · crossref published-online 2015/04/07 · openalex publication_date 2015/04/07 · crossref created 2015/04/07 · crossref published-print 2015/05/01 · crossref deposited 2024/06/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31 · crossref indexed 2026/08/01

Citations

• Markedly reduced toxicity of a hydrogen sulphide‐releasing derivative of naproxen (ATB‐346)
• Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
• Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)
• Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
• Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels
• Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-Inflammatory Nonsteroidal Drugs
• Hydrogen sulphide protects against NSAID ‐enteropathy through modulation of bile and the microbiota
• Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the Rat

Cited by

• Signalling by hydrogen sulfide and polysulfides via protein S‐sulfuration
• Hydrogen sulfide [wikipedia]