Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the Rat

2006/11/30 by John L. Wallace, Giuseppe Caliendo, Vincenzo Santagada +2 · 28 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Sulfur Compounds in Biology #Inflammatory mediators and NSAID effects #Chemotherapy-induced organ toxicity mitigation

paper · doi:10.1053/j.gastro.2006.11.042

Citations

• Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-Inflammatory Nonsteroidal Drugs

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• Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury. [europepmc]
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• The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. [europepmc]
• Anti-cancer activity of new designer hydrogen sulfide-donating hybrids. [europepmc]
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• Light-induced hydrogen sulfide release from "caged" gem-dithiols. [europepmc]
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• Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors. [europepmc]
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• Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease. [europepmc]
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• Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. [europepmc]
• Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury. [europepmc]
• NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid has enhanced chemo-preventive properties compared to aspirin, is gastrointestinal safe with all the classic therapeutic indications. [europepmc]
• Emerging Roles of Hydrogen Sulfide in Inflammatory and Neoplastic Colonic Diseases. [europepmc]
• Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. [europepmc]
• The biologic effect of hydrogen sulfide and its function in various diseases. [europepmc]
• Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors. [europepmc]
• Trends in H 2 S-Donors Chemistry and Their Effects in Cardiovascular Diseases. [europepmc]
• H 2 S Donors and Their Use in Medicinal Chemistry. [europepmc]
• Sulfide regulation of cardiovascular function in health and disease. [europepmc]
• Role of Hydrogen Sulfide in Inflammatory Bowel Disease. [europepmc]