Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-Inflammatory Nonsteroidal Drugs

2005/10/01 by Stefano Fiorucci, Elisabetta Antonelli, Eleonora Distrutti +10 · 1 voice · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Sulfur Compounds in Biology #Chemotherapy-induced organ toxicity mitigation #Inflammatory mediators and NSAID effects

paper · pdf · doi:10.1053/j.gastro.2005.07.060

Cited by

• Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the Rat
• International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors
• The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury. [europepmc]
• Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. [europepmc]
• H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. [europepmc]
• Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury. [europepmc]
• Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. [europepmc]
• Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages. [europepmc]
• Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells. [europepmc]
• Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury. [europepmc]
• Hydrogen sulfide: a gasotransmitter of clinical relevance. [europepmc]
• Hydrogen sulfide in biochemistry and medicine. [europepmc]
• Hydrogen sulfide signaling in the gastrointestinal tract. [europepmc]
• Redox Biology of Hydrogen Sulfide: Implications for Physiology, Pathophysiology, and Pharmacology. [europepmc]
• Hydrogen sulfide chemical biology: pathophysiological roles and detection. [europepmc]
• H2S and its role in redox signaling. [europepmc]
• Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. [europepmc]
• The role of H2S bioavailability in endothelial dysfunction. [europepmc]
• Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract. [europepmc]
• Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis. [europepmc]
• A timeline of hydrogen sulfide (H 2 S) research: From environmental toxin to biological mediator. [europepmc]
• Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface. [europepmc]
• Chemical Biology of H 2 S Signaling through Persulfidation. [europepmc]
• Regulation of vascular tone homeostasis by NO and H 2 S: Implications in hypertension. [europepmc]
• The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art. [europepmc]
• Disturbed homocysteine metabolism is associated with cancer. [europepmc]
• Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide. [europepmc]

Discussions

• If I were to guess, it would be that NSAIDs don't benefit cognitive aging since they interfere with hydrogen sulfide production. If anyone has other ideas on this, I would like to hear them. doi.org/ [bsky, 0 points, 1 comments]