Diastereoselective Total Synthesis of (±)‐Codeine
2008/06/18 by Marie Varin, Elvina Barré, Bogdan I. Iorga +1 · 1 citation
Chemistry · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Chemical synthesis and alkaloids #Alkaloids: synthesis and pharmacology #Cholinesterase and Neurodegenerative Diseases
paper · doi:10.1002/chem.200800744
openalex publication_date 2008/06/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Abstract
The value of a tricyclic spirocyclohexadienone intermediate has been illustrated again in the diastereoselective synthesis of (±)-codeine. From this useful intermediate, the formation of the B and D rings of codeine involved a Claisen–Eschenmoser rearrangement as a key step.
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