Total Synthesis of (±)-Morphine

2006/10/10 by Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan +1 · 2 citations
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Chemical synthesis and alkaloids #Alkaloids: synthesis and pharmacology #Advanced Synthetic Organic Chemistry

paper · doi:10.1021/ol062112m

openalex publication_date 2006/10/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/15

Abstract

[Structure: see text] The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction. Further transformation led to total synthesis of morphine.

Citations

• Asymmetric synthesis of either enantiomer of opium alkaloids and morphinans. Total synthesis of (-)- and (+)-dihydrocodeinone and (-)- and (+)-morphine
• Divergent Enantioselective Synthesis of (−)-Galanthamine and (−)-Morphine

Cited by

• Diastereoselective Total Synthesis of (±)‐Codeine
• Morphine [wikipedia]