Solubility and Melting Properties of Salicylic Acid

2006/07/11 by Fredrik L. Nordström, Åke C. Rasmuson · 150 citations
Chemistry · Materials Science · #Acetic acid #Acetone #Acetonitrile #Analytical Chemistry and Chromatography #Chemical Thermodynamics and Molecular Structure #Chemistry #Crystallization and Solubility Studies #Differential scanning calorimetry #Enthalpy #Enthalpy change of solution #Ethyl acetate #Inorganic chemistry #Melting point #Methanol #Nuclear chemistry #Organic chemistry #Salicylic acid #Solubility #Thermodynamics

paper · doi:10.1021/je060134d

published in Journal of Chemical & Engineering Data 51(5), 1668-1671 (American Chemical Society)

openalex publication_date 2006/07/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

The solubility of salicylic acid has been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate from (10 to 50) °C. No new polymorphs or solvates of salicylic acid were found. The melting properties of salicylic acid were determined by differential scanning calorimetry. A correlation was observed between the solubility and the van't Hoff enthalpy of solution. A higher solubility was related to a lower van't Hoff enthalpy of solution. Water differed from the organic solvents in terms of solubility and its correlation to the van't Hoff enthalpy of solution. In addition, the morphology of salicylic acid crystals recrystallized from water differed from the other solvents.

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