2020/09/09 by Masoud Sadeghi, Åke C. Rasmuson · 19 citations
Chemistry · Materials Science · Pharmacology, Toxicology and Pharmaceutics · #Acetone #Acetonitrile #Analytical Chemistry and Chromatography #Biochemistry #Chemistry #Crystallization and Solubility Studies #Ethyl acetate #Fenofibrate #Inorganic chemistry #Methanol #Nuclear chemistry #Organic chemistry #Pharmacological Effects of Natural Compounds #Salicylamide #Salicylic acid #Solubility
paper · doi:10.1021/acs.jced.0c00443
published in Journal of Chemical & Engineering Data 65(10), 4855-4861 (American Chemical Society)
openalex publication_date 2020/09/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In the present work, the solubility of salicylic acid, salicylamide, and fenofibrate (form I) has been determined in acetone, acetonitrile, ethyl acetate, and methanol in the range of −30 to +10 °C. Salicylic acid and salicylamide have the highest solubility in acetone and the lowest in acetonitrile. Fenofibrate has the highest solubility in ethyl acetate and the lowest in methanol. In all solvents except for acetonitrile, the solubility of salicylic acid is higher than the solubility of the other two compounds. In all solvents except for ethyl acetate, the solubility of fenofibrate is lower than the solubility of the other two compounds. In all cases, the solubility increases with increasing temperature and agrees well with the previously published data at higher temperatures. Finally, an empirical equation is fitted to the experimental data.