2011/11/29 by Remco J. Molenaar · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Ion channel regulation and function #Neuroscience and Neuropharmacology Research #Anesthesia and Neurotoxicity Research
paper · pdf · doi:10.5402/2011/590249
openalex publication_date 2011/11/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated in glioblastoma proliferation, migration, and invasion. This paper summarizes studies on potassium, sodium, chloride, and calcium channels of glioblastoma. It provides an up-to-date overview of the literature that could ultimately lead to new therapeutic targets.