Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment

2015/08/03 by Analiz Rodriguez, Stephen B. Tatter, Waldemar Debinski · 1 citation
Engineering · Materials Science · #Photoacoustic and Ultrasonic Imaging #Ultrasound and Cavitation Phenomena #Ultrasound and Hyperthermia Applications

paper · pdf · doi:10.3390/pharmaceutics7030175

openalex publication_date 2015/08/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The blood-brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood-brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood-brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal.

Citations

• Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
• Microbubble Contrast Agent with Focused Ultrasound to Create Brain Lesions at Low Power Levels: MR Imaging and Histologic Study in Rabbits
• The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure
• Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Cited by

• New name, same ethos
• Focused ultrasound for intracranial drug delivery [wikipedia]

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• Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound
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• Novel approaches to targeting gliomas at the leading/cutting edge
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