2016/04/01 by Arman Jahangiri, Aaron Chin, Patrick M. Flanigan +3 · 1 citation
Medicine · Materials Science · Biochemistry, Genetics and Molecular Biology · #Glioma Diagnosis and Treatment #Nanoparticle-Based Drug Delivery #RNA Interference and Gene Delivery
paper · pdf · doi:10.3171/2016.1.jns151591
openalex publication_date 2016/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.