An Efficient One-Pot Synthesis of Unsymmetrical Ethers: A Directly Reductive Deoxygenation of Esters Using an InBr3/Et3SiH Catalytic System

2007/06/28 by Norio Sakai, Toshimitsu Moriya, Takeo Konakahara · 1 citation
Chemistry · Biochemistry, Genetics and Molecular Biology · #Chemical Synthesis and Reactions #Chemical Synthesis and Analysis #Asymmetric Hydrogenation and Catalysis

paper · doi:10.1021/jo070814z

openalex publication_date 2007/06/28 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/26

Abstract

This study describes a novel one-pot procedure for a directly reductive conversion of the carbonyl function of esters to the corresponding ethers by Et3SiH in the presence of a catalytic amount of InBr3.

Citations

• Reduction of carboxylic esters to ethers with triethyl silane in the combined use of titanium tetrachloride and trimethylsilyl trifluoromethanesulfonate
• Facile reduction of ethyl thiol esters to aldehydes: application to a total synthesis of (+)-neothramycin A methyl ether

Cited by

• Ester [wikipedia]

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