InCl3-Catalyzed Reductive Coupling of Aromatic Carbonyl Compounds in the Presence of Magnesium and Chlorotrimethylsilane

2001/08/01 by Kenji Mori, Seiji Ohtaka, Sakae Uemura
Chemistry · #Asymmetric Hydrogenation and Catalysis #Chemical Synthesis and Reactions #Oxidative Organic Chemistry Reactions

paper · doi:10.1246/bcsj.74.1497

crossref issued 2001/08/01 · crossref published 2001/08/01 · crossref published-print 2001/08/01 · openalex publication_date 2001/08/01 · crossref published-online 2002/10/01 · crossref created 2002/10/01 · openalex created_date 2016/06/24 · crossref deposited 2024/01/20 · openalex updated_date 2026/06/26 · crossref indexed 2026/07/30

Abstract

Abstract Reductive homocoupling of aromatic aldehydes and ketones has been achieved in tetrahydrofuran at room temperature using a catalytic amount of InCl3 (0.005–0.1 molar amount) under nitrogen atmosphere in the presence of both chlorotrimethylsilane and magnesium metal (Mg turnings) to provide the corresponding 1,2-diols in good to moderate yields with a high diastereoselectivity.

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