Limb Regeneration: A New Development?

2011/03/03 by Eugen Nacu, Elly M. Tanaka · 158 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Anatomy #Axolotl #Biology #Cell biology #Computer science #Congenital heart defects research #Developmental Biology and Gene Regulation #Ecology #Embryo #Genetics #Hippo pathway signaling and YAP/TAZ #Limb development #Morphogenesis #Neuroscience #Process (computing) #Regeneration (biology) #Salamander

paper · doi:10.1146/annurev-cellbio-092910-154115

published in Annual Review of Cell and Developmental Biology 27(1), 409-440 (Annual Reviews)

openalex publication_date 2011/03/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

Salamander limb regeneration is a classical model of tissue morphogenesis and patterning. Through recent advances in cell labeling and molecular analysis, a more precise, mechanistic understanding of this process has started to emerge. Long-standing questions include to what extent limb regeneration recapitulates the events observed in mammalian limb development and to what extent are adult- or salamander- specific aspects deployed. Historically, researchers studying limb development and limb regeneration have proposed different models of pattern formation. Here we discuss recent data on limb regeneration and limb development to argue that although patterning mechanisms are likely to be similar, cell plasticity and signaling from nerves play regeneration-specific roles.

Citations

• The Newt Ortholog of CD59 Is Implicated in Proximodistal Identity during Amphibian Limb Regeneration
• Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
• Positional information and the spatial pattern of cellular differentiation
• Glial growth factor and nerve-dependent proliferation in the regeneration blastema of urodele amphibians
• The failure of double‐half forelimbs to undergo distal transformation following amputation in the axolotl, Ambystoma mexicanum
• Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate

Cited by

• Developmental biology [wikipedia]

Related

• Model systems for regeneration: salamanders
• Limb regeneration
• Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate
• Morphological, Molecular, and Hormonal Basis of Limb Regeneration across Pancrustacea: Table 1
• Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning