2019/07/15 by Alberto Joven, Ahmed Elewa, András Simon · 5 citations
Biochemistry, Genetics and Molecular Biology · Earth and Planetary Sciences · Environmental Science · #Marine Ecology and Invasive Species #Planarian Biology and Electrostimulation #Subterranean biodiversity and taxonomy
paper · pdf · doi:10.1242/dev.167700
openalex publication_date 2019/07/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Salamanders have been hailed as champions of regeneration, exhibiting a remarkable ability to regrow tissues, organs and even whole body parts, e.g. their limbs. As such, salamanders have provided key insights into the mechanisms by which cells, tissues and organs sense and regenerate missing or damaged parts. In this Primer, we cover the evolutionary context in which salamanders emerged. We outline the varieties of mechanisms deployed during salamander regeneration, and discuss how these mechanisms are currently being explored and how they have advanced our understanding of animal regeneration. We also present arguments about why it is important to study closely related species in regeneration research.