Trans Fatty Acids and Cardiovascular Disease

2006/04/12 by Dariush Mozaffarian, Mira Katan, Alberto Ascherio +2 · 14 citations
Nursing · Medicine · Biochemistry, Genetics and Molecular Biology · #Fatty Acid Research and Health #Natural Products and Biological Research #Lipid metabolism and biosynthesis

paper · doi:10.1056/nejmra054035

openalex publication_date 2006/04/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The intake of trans fat has been associated with coronary heart disease, sudden death from cardiac causes, and diabetes. This article reviews the evidence for physiological and cellular effects of trans fatty acids, unsaturated fatty acids with at least one double bond in the trans configuration. The authors consider the feasibility and potential implications of reducing or eliminating the consumption of trans fatty acids from partially hydrogenated vegetable oils in the United States.

Cited by

• Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association
• European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts)
• Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies
• Position of the American Dietetic Association and Dietitians of Canada: Dietary Fatty Acids
• Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials
• Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils
• Nutrition transition and its relationship to the development of obesity and related chronic diseases
• Dietary trans fatty acids: Review of recent human studies and food industry responses
• Trans fatty acids: Effects on cardiometabolic health and implications for policy
• Trans fatty acids and cardiovascular risk: A unique cardiometabolic imprint?
• Global obesity: trends, risk factors and policy implications
• Heart Disease and Stroke Statistics—2012 Update
• Coronary artery disease [wikipedia]
• Fat [wikipedia]