The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

2010/09/21 by Yucheng Xiao, Kenneth Blumenthal, Kenneth M. Blumenthal +4 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Ion channel regulation and function #Nicotinic Acetylcholine Receptors Study #Venomous Animal Envenomation and Studies

paper · pdf · doi:10.1124/mol.110.066332

openalex publication_date 2010/09/21 · crossref created 2010/09/21 · crossref issued 2010/12/01 · crossref published 2010/12/01 · crossref published-print 2010/12/01 · openalex created_date 2016/06/24 · crossref deposited 2025/02/19 · crossref indexed 2026/06/05 · openalex updated_date 2026/07/22

Citations

• ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

Cited by

• Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides
• The Role of Voltage-Gated Sodium Channels in Pain Signaling
• Protoxin-II [wikipedia]