ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

2008/08/26 by William A. Schmalhofer, Jeffrey D. Calhoun, Jeffrey Calhoun +11 · 9 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Ion Channels and Receptors #Ion channel regulation and function #Pain Mechanisms and Treatments

paper · doi:10.1124/mol.108.047670

openalex publication_date 2008/08/26 · crossref created 2008/08/26 · crossref issued 2008/11/01 · crossref published 2008/11/01 · crossref published-print 2008/11/01 · openalex created_date 2016/06/24 · crossref deposited 2025/02/20 · crossref indexed 2026/07/23 · openalex updated_date 2026/07/25

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• The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
• The NAv1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing
• Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
• Spider-Venom Peptides as Therapeutics
• Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides
• The Role of Voltage-Gated Sodium Channels in Pain Signaling
• Protoxin-II [wikipedia]