Efficient Stereoselective Synthesis of Catechin Trimer Derivative Using Silver Lewis Acid-Mediated Equimolar Condensation

2011/01/01 by Hidefumi Makabe, Yukiko Oizumi, Yoshihiro Mohri +1 · 1 citation
Medicine · #Tea Polyphenols and Effects #Synthesis of Organic Compounds #Phytochemicals and Antioxidant Activities

paper · doi:10.3987/com-11-12159

openalex publication_date 2011/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/02

Abstract

A stereoselective synthesis of benzylated catechin trimer under intermolecular condensasion is achieved using equimolar amount of dimeric catechin nucleophile and monomeric catechin electrophile catalyzed by AgOTf or AgBF(4). The coupled product can be transformed into procyanidin C2 by a known procedure.

Citations

• Efficient Stereoselective Synthesis of Proanthocyanidin Trimers with TMSOTf-Catalyzed Intermolecular Condensation
• Oligomeric proanthocyanidins: naturally occurring O-heterocycles

Cited by

• B type proanthocyanidin [wikipedia]

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