Enantioselective catalytic Urech hydantoin synthesis

2025/01/01 by Wen-Ya Zheng, Ziqi Wang, Xing-Zi Li +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · #Advanced Synthetic Organic Chemistry #Biochemical and Molecular Research #Chemical Reactions and Mechanisms

paper · doi:10.1039/d5qo00378d

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

The first catalytic enantioselective Urech synthesis is developed via organocatalytic desymmetrization and kinetic resolution. Using easily available malonic esters and isothiocyanates as substrates, various hydantoins with aza-quaternary stereocenters are formed under simple conditions.

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