Borrowing Hydrogen in the Activation of Alcohols

2007/07/02 by Malai Haniti S. A. Hamid, Paul A. Slatford, Jonathan M. J. Williams · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Asymmetric Hydrogenation and Catalysis #Chemical Synthesis and Analysis #Organoboron and organosilicon chemistry

paper · doi:10.1002/adsc.200600638

openalex publication_date 2007/07/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02

Abstract

Abstract Alcohols can be temporarily converted into carbonyl compounds by the metal‐catalysed removal of hydrogen. The carbonyl compounds are reactive in a wider range of transformations than the precursor alcohols and can react in situ to give imines, alkenes, and α‐functionalised carbonyl compounds. The metal catalyst, which had borrowed the hydrogen, then returns it to the transformed carbonyl compound, leading to an overall process in which alcohols can be converted into amines, compounds containing CC bonds and β‐functionalised alcohols.

Citations

• Lipase-Catalyzed Dynamic Kinetic Resolution of Chiral Amines: Use of Palladium as the Racemization Catalyst
• Practical Enantioselective Hydrogenation of Aromatic Ketones

Cited by

• Catalytic Transfer Functionalization through Shuttle Catalysis
• (Cymene)ruthenium dichloride dimer [wikipedia]

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