Lipase-Catalyzed Dynamic Kinetic Resolution of Chiral Amines: Use of Palladium as the Racemization Catalyst

1996/12/18 by Manfred T. Reetz, Klaus Schimossek
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Analytical Chemistry and Chromatography #Enzyme Catalysis and Immobilization #Pharmacogenetics and Drug Metabolism

paper · pdf · doi:10.2533/chimia.1996.668

crossref issued 1996/12/18 · crossref published 1996/12/18 · crossref published-online 1996/12/18 · openalex publication_date 1996/12/18 · crossref created 2022/04/13 · crossref deposited 2022/09/25 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/30

Abstract

The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77% (ee = 99%).

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