2007/07/30 by Gemma E. Veitch, Edith Beckmann, Brenda J. Burke +3 · 2 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Insect Pest Control Strategies #Phytochemical compounds biological activities #Traditional and Medicinal Uses of Annonaceae
paper · doi:10.1002/anie.200703027
openalex publication_date 2007/07/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
22 Years in the making: Azadirachtin (1) was synthesized for the first time by a highly convergent approach, utilizing a Claisen rearrangement and a radical cyclization as key steps. End-game strategies relied on intermediate 2, which could be obtained by synthetic methods as well as by degradation of 1. Bn=benzyl, TBS=tert-butyldimethylsilyl.