A Synthesis of Calothrixin B

2004/10/20 by André Guingant, Drissa Sissouma, Sylvain Collet
Medicine · Chemistry · Biochemistry, Genetics and Molecular Biology · #Microbial Natural Products and Biosynthesis #Synthetic Organic Chemistry Methods #Marine Sponges and Natural Products

paper · doi:10.1055/s-2004-834831

Abstract

A new short and efficient synthesis of calothrixin B is ­reported. The key reaction is a hetero-Diels-Alder reaction between 3-bromo-9H-carbazole-1,4-dione and a 'push-pull' 2-aza-1,3-diene.

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