A Phosphine‐Mediated Conversion of Azides into Diazo Compounds

2008/11/26 by Eddie L. Myers, Ronald T. Raines · 3 citations
Chemistry · #Azide #Catalysis #Chemistry #Click Chemistry and Applications #Combinatorial chemistry #Cyclopropane Reaction Mechanisms #Diazo #Organic chemistry #Phosphine #Staudinger reaction #Synthesis and Catalytic Reactions #Triazene

paper · doi:10.1002/anie.200804689

openalex publication_date 2008/11/26 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Abstract

N2 the mild: Diazo compounds are extremely versatile intermediates for synthetic organic chemistry, but their synthesis can be challenging in the presence of delicate functional groups. The Staudinger ligation has inspired a mild method for the conversion of a broad range of azides into their diazo compound derivatives through an acyl triazene intermediate.

Citations

• The Use of Tosylhydrazone Salts as a Safe Alternative for Handling Diazo Compounds and Their Applications in Organic Synthesis

Cited by

• New Syntheses of Diazo Compounds
• Catalytic Carbene Insertion into C−H Bonds
• Diazo [wikipedia]

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