2024/12/04 by Kirti Devi, Asad Shehzad, Mario P. Wiesenfeldt · 1 voice
Chemistry · #Radical Photochemical Reactions #Catalytic C–H Functionalization Methods #Sulfur-Based Synthesis Techniques
paper · doi:10.1021/jacs.4c14669
openalex publication_date 2024/12/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
) content is known to correlate with clinical success. Cyclohexenes are attractive targets, as they can be rapidly elaborated into large product libraries and are stable against rearomatization. However, partial reduction reactions of benzenes to cyclohexenes are rare and have a very narrow scope. Herein we report a broadly applicable method that converts electron-poor benzenes to cyclohexenes and tolerates Lewis-basic functional groups such as triazoles and thioethers as well as reducible groups such as cyanides, alkynes, and sulfones. The reaction utilizes an organic donor that induces mild arene reduction by preassociation to a photoexcitable electron donor-acceptor (EDA) complex and mild isomerization of redox-inert 1,4-cyclohexadienes to reducible 1,3-cyclohexadienes without a strong base in its oxidized thioquinone methide form.