2024/09/16 by Torsten Linker · 1 voice · 1 citation
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Asymmetric Hydrogenation and Catalysis #Chemical Reactions and Isotopes #Coordination Chemistry and Organometallics
paper · doi:10.1055/a-2415-9520
openalex publication_date 2024/09/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
Abstract The Birch reduction has found a renaissance during the last two decades. In this Synpacts article a short summary of selected recent synthetic applications will be provided. 1,4-Cyclohexadienes, which are formed by Birch reduction in one step, are suitable precursors for radical reactions and are used as surrogates for difficult-to-handle substances. Their rearomatization under acidic conditions offers easy access to selectively alkylated arenes. Additionally, the Birch reduction of benzoic acids and subsequent trapping afford spiro compounds in high yields. Very recently, it was shown that 1,3-cyclohexadienes are directly available by Birch reduction in a one-pot reaction as well. 1 Introduction 2 Rearomatizations 3 Synthesis of Spiro Compounds 4 Synthesis of 1,3-Cyclohexadienes 5 Conclusion