Recent Synthetic Strategies to Access Seven-Membered Carbocycles in Natural Product Synthesis

2013/03/04 by Dieter Enders, Thanh Nguyen, Thành Vinh Nguyễn +1 · 1 citation
Chemistry · Medicine · #Synthetic Organic Chemistry Methods #Oxidative Organic Chemistry Reactions #Microbial Natural Products and Biosynthesis

paper · doi:10.1055/s-0032-1318152

Abstract

This methodology-oriented review covers the synthetic strategies to construct seven-membered carbocycles in naturally occurring compounds over the last ten years. It offers an insight into the common synthetic targets and approaches and provides useful information for further developments within this area of natural product synthesis as well as synthetic methodology in general. 1 Introduction 2 Cyclization Reactions 3 Cycloaddition Reactions 3.1 [5+2] Cycloaddition 3.2 [4+3] Cycloaddition 3.3 Diels–Alder Reactions 3.4 [2+2+2] Cycloaddition 4 Ring-Closing Metathesis 4.1 Ene–Ene Metathesis 4.2 Ene–Yne Metathesis 5 Ring-Expansion and Ring-Contraction Reactions 5.1 Ring-Expansion Reactions 5.2 Ring-Contraction Reactions 6 Fragmentation and Isomerization Reactions 7 Other Frequently Targeted Natural Products 8 Conclusion

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