Harnessing Organopotassium Reagents for Cross-Coupling with YPhos-Pd Catalysts: Opportunities, Applications, and Challenges

2025/02/02 by Daniel Knyszek, Julian Löffler, David E. Anderson +2 · 1 voice
Chemistry · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Asymmetric Hydrogenation and Catalysis

paper · pdf · doi:10.1021/jacs.4c18073

openalex publication_date 2025/02/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

With advances in the applications of earth-abundant organopotassium reagents in C-C bond forming processes, this study pioneers Pd-catalyzed cross coupling reactions between aryl halides and a range of aryl and benzylpotassium species generated by direct C-H metalation. Key for the success of this approach is the use of electron-rich ylide-substituted phosphine (YPhos) ligands, which enable fast conversion of the potassium species in solution. This protocol can be carried out in a one-pot manner at room temperature, without the need for purification of the in situ prepared organopotassium compounds or any additional additives, enabling the isolation of a broad scope of coupling products even on a gram-scale.

Discussions

• #RobSelects paper of the week #J_A_C_S: Pd-catalyzed cross-coupling of organopotassium reagents with aryl halides. #catalysis https://doi.org/10.1021/jacs.4c18073 [bsky, 0 points, 0 comments]

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