Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation

2025/01/01 by Jinghua Wu, H. Li, Adam R. Lovato +3 · 1 voice
Engineering · #Innovative Microfluidic and Catalytic Techniques Innovation

paper · pdf · doi:10.1039/d5cb00159e

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

histone monoaminylation analysis. Overall, our findings in this research expanded the chemical biology toolbox for investigating histone monoaminylation and facilitated the understandings of TAD-mediated ene-type reactions.

Citations

• Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

Discussions

• 🚨 Breakthrough in targeting cancer-related protein aggregation: "Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Fri [bsky, 0 points, 0 comments]

Related

• The Future of Bioorthogonal Chemistry
• Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective
• Crotonylation and disease: Current progress and future perspectives
• Chemical biology tools for studying histone post-translational modifications
• The reactome pathway knowledgebase 2022