2021/10/14 by Marc Gillespie, Bijay Jassal, Ralf Stephan +32 · 22 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Computer Science · #Advanced Proteomics Techniques and Applications #Bioinformatics and Genomic Networks #Computational Drug Discovery Methods
paper · pdf · doi:10.1093/nar/gkab1028
openalex publication_date 2021/10/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.