2023/06/29 by Ping Yang, Yuanyuan Qin, Lisha Zeng +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Histone Deacetylase Inhibitors Research #Signaling Pathways in Disease #Ubiquitin and proteasome pathways
paper · doi:10.1016/j.biopha.2023.115108
openalex publication_date 2023/06/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Histone lysine crotonylation was first identified as a new type of post-translational modification in 2011. In recent years, prominent progress has been made in the study of histone and nonhistone crotonylation in reproduction, development, and disease. Although the regulatory enzyme systems and targets of crotonylation partially overlap with those of acetylation, the peculiar CC bond structure of crotonylation suggests that crotonylation may have specific biological functions. In this review, we summarize the latest research progress regarding crotonylation, especially its regulatory factors and relationship with diseases, which suggest further research directions for crotonylation and provide new ideas for developing disease intervention and treatment regimens.