A Novel Trypsin‐Catalyzed Three‐Component Mannich Reaction

2010/11/01 by She‐Jie Chai, Yi‐Feng Lai, Yifeng Lai +3 · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Acetone #Asymmetric Synthesis and Catalysis #Carbohydrate Chemistry and Synthesis #Catalysis #Chemical Synthesis and Analysis #Chemistry #Combinatorial chemistry #Component (thermodynamics) #Enzyme #Mannich reaction #Organic chemistry #Trypsin

paper · doi:10.1002/hlca.201000063

openalex publication_date 2010/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Abstract We found that the trypsin from hog pancreas displayed high activity to promote three‐component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate‐to‐excellent yields. The reaction tolerates a great range of substrates and extends the application of trypsin in organic synthesis.

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