2011/01/01 by Vishal Kumar, Upendra Sharma, Praveen Kumar Verma +2
Biochemistry, Genetics and Molecular Biology · Chemistry · #Asymmetric Synthesis and Catalysis #Chemical Synthesis and Analysis #Chemical Synthesis and Reactions
paper · pdf · doi:10.1248/cpb.59.639
crossref issued 2011/01/01 · crossref published 2011/01/01 · crossref published-print 2011/01/01 · openalex publication_date 2011/01/01 · crossref created 2011/05/02 · crossref deposited 2017/06/19 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/07/31
A rapid and efficient silica-supported boric acid/ionic liquid ([bmim][PF₆]), catalyzed, one-pot three-component Mannich reaction has been carried out to synthesize β-amino carbonyl compounds at room temperature. The reaction afforded desired products in excellent yields with moderate to good diastereoselectivity. The method provides a novel modification of three-component Mannich reaction in terms of mild reaction conditions, clean reaction profiles, low amount of catalyst, recyclability of catalyst and a simple workup procedure. The present report first time describes the preparation of H₃BO₃-SiO₃ catalyst and its use with [bmim][PF₆], to synthesize Mannich products. The catalyst can be reused at least seven times.