Syntheses of the Macrocyclic Spermine Alkaloids (±)-Budmunchiamine A - C

2001/01/31 by Kasim Popaj, Manfred Hesse · 2 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Polyamine Metabolism and Applications #Antimicrobial Peptides and Activities #Phenothiazines and Benzothiazines Synthesis and Activities

paper · doi:10.1002/1522-2675(20010131)84:1<180::aid-hlca180>3.0.co;2-f

Abstract

The syntheses of four macrocyclic spermine alkaloids, (±)-budmunchiamine A – C (1a – c) and (±)-budmunchiamine L4 (1), were accomplished by Michael addition of spermine to the α,β-unsaturated esters 3a – d, followed by cyclization of the resulting α,ω-tetraamino esters 4a – d with triethoxyantimony; N-methylation of the amino lactams 6a – c yielded the budmunchiamines A – C (1a – c).

Cited by

• GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents. [europepmc]
• Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies. [europepmc]

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