Organo-cation-catalyzed site-selective sequential alkylation of dimeric 2-oxindoles: a concise catalytic approach to (+)-calycanthidine and (+)-idiospermuline

2025/12/01 by Pranay Shyamal, Debabrata Mondal, Arindam Khatua +2 · 1 voice
Chemistry · #Advanced Synthetic Organic Chemistry #Asymmetric Synthesis and Catalysis #Chemical synthesis and alkaloids

paper · doi:10.1039/d5qo01482d

openalex created_date 2025/12/01 · openalex publication_date 2025/12/01 · openalex updated_date 2026/06/11

Abstract

The total synthesis of bis(cyclotryptamine) alkaloids has been realized via the development of an organo-cation-catalyzed (C5) site-selective, enantioselective (94% ee) and diastereoselective (dr > 20 : 1) sequential alkylation.

Discussions

• Hot research by Alakesh Bisai's team. #IISERKOL Authors develop an organocatalytic, enantio- and diastereoselective alkylation strategy enabling efficient synthesis of bis(cyclotryptamine) alkaloids [bsky, 1 points, 0 comments]

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