Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut

2026/03/02 by Shan Liu, Marina Domingo-Vidal, Bhoomi Madhu +3 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Gut microbiota and health #Metabolomics and Mass Spectrometry Studies #Nutrition, Genetics, and Disease

paper · doi:10.1038/s41575-026-01178-9

crossref issued 2026/03/02 · crossref published 2026/03/02 · crossref published-online 2026/03/02 · openalex publication_date 2026/03/02 · crossref created 2026/03/02 · openalex created_date 2026/03/03 · crossref published-print 2026/06/01 · crossref deposited 2026/06/02 · crossref indexed 2026/07/21 · openalex updated_date 2026/07/29

Citations

• Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases
• Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
• Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
• Mannose ameliorates experimental colitis by protecting intestinal barrier integrity
• Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases
• Serotonin reduction in post-acute sequelae of viral infection
• Short-chain fatty acids: linking diet, the microbiome and immunity
• Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer
• RELMβ sets the threshold for microbiome-dependent oral tolerance

Discussions

• 3. A new review in @natrevgastrohep.nature.com from senior author and ACS grantee @maayanlevy.bsky.social that described a conceptual overview of the recurring mechanistic themes by which metabolites [bsky, 2 points, 1 comments]