Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

2017/08/19 by Susanna Nikolaus, Berenice Schulte, Natalie Al-Massad +16 · 38 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Tryptophan and brain disorders #Gut microbiota and health #Inflammatory Bowel Disease

paper · doi:10.1053/j.gastro.2017.08.028

Cited by

• Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine
• Essential Amino Acid Metabolites as Chemical Mediators of Host-Microbe Interaction in the Gut
• The Gut Microbiome and Inflammatory Bowel Diseases
• Novel cross-feeding human gut microbes metabolizing tryptophan to indole-3-propionate
• Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay
• Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut
• Deciphering the microbiome–metabolome landscape of an inflammatory bowel disease inception cohort
• Cytochrome P450 Cyp2s1 regulation of the intestinal metabolome and microbiome
• Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice
• β-ionone prevents dextran sulfate sodium-induced ulcerative colitis and modulates gut microbiota in mice
• Tryptophan metabolism in health and disease
• Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development
• Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
• Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. [europepmc]
• Microbial tryptophan catabolites in health and disease. [europepmc]
• ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. [europepmc]
• The Role of Dietary Nutrients in Inflammatory Bowel Disease. [europepmc]
• Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. [europepmc]
• Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome. [europepmc]
• Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine. [europepmc]
• Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development. [europepmc]
• Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and Disease. [europepmc]
• The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease. [europepmc]
• Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals. [europepmc]
• The aryl hydrocarbon receptor as a mediator of host-microbiota interplay. [europepmc]
• Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases. [europepmc]
• Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation. [europepmc]
• Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. [europepmc]
• The Gut Microbiome and Inflammatory Bowel Diseases. [europepmc]
• Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD. [europepmc]
• New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases. [europepmc]
• The Gut Microbiota in Inflammatory Bowel Disease. [europepmc]
• Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases. [europepmc]
• Disturbances of the Gut Microbiota and Microbiota-Derived Metabolites in Inflammatory Bowel Disease. [europepmc]
• Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes. [europepmc]
• Inflammatory Bowel Diseases and Gut Microbiota. [europepmc]
• The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases. [europepmc]
• Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding. [europepmc]